San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

One of the best receivers in the league will be on display when George Kittle and the San Francisco 49ers visit the Buffalo ...

The Buffalo Bills (9-2) take a six-game winning streak into their contest with the San Francisco 49ers on Sunday, December 1, ...

Buffalo Bills linebacker Matt Milano (58) reacts after a defensive play against the New York Jets during the first quarter of ...

Ten months after their wild-card playoff game against the Pittsburgh Steelers was postponed due to blizzard conditions, the ...

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff ...

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio ...

Watch out for the tables on "Sunday Night Football." The nightcap of Sunday's action will be in northern New York with the ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

San Francisco played without four key players - quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...