San Francisco 49ers quarterback Brock Purdy missed last week's game against the Green Bay Packers. Will he play against the ...

The Bills attempt to win seven in a row when they host the 49ers in this Week 13 NFL odds, prediction, and pick.

On Tuesday, we reported on Buffalo’s sterling record following bye weeks under Head Coach Sean McDermott, which was quickly ...

What to expect from Sunday Night Football's 49ers vs. Bills matchup. This is one of those games that feels like Buffalo's to ...

The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on "Sunday Night Football" in Week 13. The ...

Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

Here are the Week 13 games that will impact the 49ers’ playoff chances and which team the 49ers need to win: 49ers need: A ...

Here are the full injury reports for the Buffalo Bills and San Francisco 49ers ahead of their Week 13 matchup at Highmark ...

The Buffalo Bills might have a chance to clinch the AFC East on Sunday night when they battle the injury-decimated San ...

In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers ...

The Green Bay Packers are back in primetime for the first of four consecutive night games, and it's a big one.