The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with ...

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

After games on both Thanksgiving and Black Friday, the NFL caps off the Sunday slate with the Buffalo Bills hosting the San ...

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five ...

Heads have already started to roll at the San Francisco 49ers. Entering the final third of the regular season, management ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

Buffalo Bills offensive stars prepare to shine against the San Francisco 49ers' struggling defense in a critical AFC-NFC ...

Preview the Week 13 matchup between the Buffalo Bills and San Francisco 49ers with predictions, odds, over/under, spread, ...

The Buffalo Bills have activated Matt Milano from injured reserve, putting the starting linebacker in position to play Sunday ...

The San Francisco 49ers were among the Super Bowl favorites heading into the season, but they find themselves below the .500 ...

The #Bills have activated Pro Bowl LB Matt Milano off Injured Reserve and he’ll play on Sunday against the #49ers for the ...